Default mode network alterations during implicit emotional faces processing in first-episode, treatment-naive major
Huqing Shi1, Xiang Wang2, Jinyao Yi2
1Medical Psychological Institute, Second Xiangya Hospital, Central South University , Changsha, China ; Department of Psychology, Shanghai Normal University , Shanghai, China.
Frontiers in Psychology
|September 1, 2015
Summary
Major depressive disorder (MDD) patients show altered default mode network (DMN) activity during emotional tasks. This brain connectivity difference in major depressive disorder may link to emotional regulation difficulties.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Science
Background:
- Previous research highlights resting-state default mode network (DMN) alterations in depression.
- Limited and inconsistent findings exist regarding DMN changes during task-related processing in major depressive disorder (MDD).
Purpose of the Study:
- To investigate DMN patterns during implicit emotional processing in young adults with first-episode, treatment-naïve major depressive disorder (MDD).
- To explore the relationship between DMN functional connectivity and emotional regulation in MDD patients.
Main Methods:
- Functional magnetic resonance imaging (fMRI) was used to assess brain activity in MDD patients (N=29) and healthy controls (N=33) at rest and during a gender judgment task.
- Group independent component analysis (ICA) identified DMN components under task conditions.
- The Cognitive Emotion Regulation Questionnaire (CERQ) assessed emotional regulation strategies.
Main Results:
- MDD patients exhibited decreased DMN functional connectivity in bilateral prefrontal areas compared to controls.
- Reduced right prefrontal gyrus connectivity in MDD patients negatively correlated with maladaptive cognitive emotion regulation scores.
Conclusions:
- Depressed individuals display altered DMN patterns during implicit emotional processing.
- These DMN alterations may underlie impaired internal monitoring and emotional regulation abilities in major depressive disorder.
Keywords:
default mode networkemotional faces processingfunctional magnetic resonance imagingindependent component analysismajor depressive disorderMore Related Videos
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