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Related Concept Videos

Complement System01:27

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Related Experiment Video

Updated: Apr 4, 2026

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
12:14

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Complement in the Homeostatic and Ischemic Brain.

Ali Alawieh1, Andrew Elvington2, Stephen Tomlinson3

  • 1Neuroscience Institute, Department of Neurosciences, Medical University of South Carolina , Charleston, SC , USA.

Frontiers in Immunology
|September 1, 2015
PubMed
Summary
This summary is machine-generated.

The complement system aids immune response but can worsen stroke injury. Understanding its dual role in brain repair is key for developing effective stroke therapies.

Keywords:
brain ischemiacomplementinnate immunityneuroprotectionreperfusion injurystroke

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Area of Science:

  • Neuroscience
  • Immunology
  • Pathology

Background:

  • The complement system is crucial for immune responses against pathogens.
  • Complement activation contributes to brain damage after cerebral ischemia and reperfusion.
  • The complement system also plays vital roles in normal brain functions like synaptic pruning and neurogenesis.

Purpose of the Study:

  • To review the multifaceted role of the complement system in the brain.
  • To examine complement activation following ischemic stroke and its contribution to injury.
  • To discuss complement's dual role in both neurodegeneration and neuro-repair after stroke.

Main Methods:

  • Literature review of complement system functions in the central nervous system.
  • Analysis of complement activation pathways after cerebral ischemia-reperfusion.
  • Synthesis of evidence on complement's impact on stroke pathophysiology and recovery.

Main Results:

  • Complement activation exacerbates acute ischemic stroke injury via inflammation.
  • Complement also mediates essential processes for brain recovery and plasticity.
  • Inhibition of complement may be beneficial acutely but could impair long-term recovery.

Conclusions:

  • The complement system has a dual role in stroke, causing injury and aiding recovery.
  • Targeting the complement system for stroke therapy requires careful consideration of its complex functions.
  • Further research is needed to elucidate complement's precise roles in different stroke phases for therapeutic development.