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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
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SGF29 and Sry pathway in hepatocarcinogenesis.
Nobuya Kurabe1, Shigekazu Murakami1, Fumio Tashiro1
1Nobuya Kurabe, Department of Tumor Pathology, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.
World Journal of Biological Chemistry
|September 1, 2015
Summary
Elevated SAGA-associated factor 29 (SGF29) drives hepatocellular carcinoma (HCC) by upregulating c-Myc. This deregulated Sry-SGF29 pathway may explain male-specific HCC development.
Area of Science:
- Molecular biology
- Oncology
- Biochemistry
Background:
- Deregulated c-Myc expression is a common feature in human cancers.
- SAGA-associated factor 29 (SGF29), a component of the mammalian SPT3-TAF9-GCN5-acetyltransferase complex, regulates c-Myc.
- Hepatocellular carcinoma (HCC) is a significant global health concern, with a notable male predominance.
Purpose of the Study:
- To elucidate the molecular mechanism of SGF29 in regulating c-Myc overexpression in HCC.
- To investigate the role of sex-determining region Y (Sry) in the upstream regulation of SGF29 in HCC.
- To explore the hypothesis that deregulated Sry-SGF29 pathway contributes to male-specific HCC development.
Main Methods:
- Analysis of the molecular nature of SGF29 within the SPT3-TAF9-GCN5-acetyltransferase complex.
- Investigation of the mechanism linking elevated SGF29 expression to c-Myc's oncogenic potential in HCC.
- Examination of Sry-mediated upstream regulation of SGF29 in HCC models.
Main Results:
- SGF29 plays a crucial role in regulating c-Myc overexpression in HCC.
- Elevated SGF29 expression contributes to the oncogenic potential of c-Myc in HCC.
- Sry-mediated regulation of SGF29 is augmented in HCC, suggesting a link to male-specific tumorigenesis.
Conclusions:
- The Sry-SGF29 pathway is a key driver of c-Myc elevation in HCC.
- This pathway is implicated in the male-specific incidence of human HCC.
- Targeting the Sry-SGF29-c-Myc axis may offer novel therapeutic strategies for HCC.
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