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Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs

Johan Vande Voorde1, Peter Vervaeke1, Sandra Liekens1

  • 1Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, blok x - bus 1030, B-3000 Leuven, Belgium.

FEBS Open Bio
|September 1, 2015
PubMed

Keywords:
(d)Ado, (2′-deoxy)adenosine(d)Guo, (2′-deoxy)guanosine(d)Ino, (2′-deoxy)inosine(d)Urd, (2′-deoxy)uridine3TC, 2′,3′-dideoxy-3′-thiacytidineCDA, cytidine deaminaseCancerCytidine deaminaseGemcitabineImm-H, Immucillin-HMycoplasmaNA, nucleoside analogueNucleoside analoguePNP, purine nucleoside phosphorylasePurine nucleoside phosphorylaseara-Cyd, cytosine arabinosidedFdC, gemcitabinedFdU, 2′,2′-difluoro-2′-deoxyuridinedThd, thymidineddC, 2′,3′-dideoxycytidine

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