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Micronutrient in hyperphenylalaninemia.

Vanesa Crujeiras1, Luís Aldámiz-Echevarría2, Jaume Dalmau3

  • 1Unit of Gastroenterology and Nutrition, Department of Pediatrics, Hospital Clinico Universitario de Santiago, Travesía da Choupana s/n, 15706 Santiago de Compostela, A Coruña, Spain.

Data in Brief
|September 1, 2015
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Summary
This summary is machine-generated.

Biochemical data from 156 patients with phenylketonuria (PKU) reveal common prealbumin and selenium deficiencies. Many also showed elevated folic acid levels, highlighting key nutritional concerns in PKU management.

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Area of Science:

  • Biochemistry
  • Clinical Nutrition
  • Metabolic Disorders

Background:

  • Phenylketonuria (PKU) is a metabolic disorder requiring strict dietary management.
  • Patients with PKU follow a low-protein diet supplemented with amino acids, vitamins, and minerals.
  • Nutritional status monitoring is crucial for managing PKU patients.

Purpose of the Study:

  • To present biochemical parameters of 156 patients diagnosed with hyperphenylalaninemia.
  • To identify common nutritional deficiencies and excesses in PKU patients undergoing dietary treatment.
  • To provide data related to vitamin and mineral status in this patient cohort.

Main Methods:

  • Biochemical analysis of blood samples from 156 hyperphenylalaninemia patients.
  • Assessment of serum prealbumin, selenium, and folic acid levels.
  • Data collection from patients adhering to a specialized low-protein diet.

Main Results:

  • A high percentage of patients exhibited prealbumin deficiency.
  • Significant selenium deficiencies were observed in the studied population.
  • Elevated levels of folic acid were a common finding among the patients.

Conclusions:

  • Dietary management of PKU may lead to specific nutrient deficiencies, notably prealbumin and selenium.
  • Increased folic acid levels warrant further investigation in PKU patients.
  • These findings underscore the importance of tailored nutritional monitoring for individuals with PKU.