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    Cancer can lead to stroke through various mechanisms, including hypercoagulability and tumor compression. This review proposes screening for occult malignancy in patients with cryptogenic stroke.

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    Area of Science:

    • Neurology
    • Oncology
    • Cardiovascular Medicine

    Background:

    • The relationship between cancer and stroke is intricate and multifactorial.
    • Cancer can precipitate stroke through hypercoagulability, non-bacterial thrombotic endocarditis (NBTE), direct vascular compression, or treatment side effects.

    Purpose of the Study:

    • To review the existing data linking stroke and cancer.
    • To propose a screening algorithm for occult malignancy in patients presenting with cryptogenic stroke.

    Main Methods:

    • Literature review of studies investigating the association between stroke and cancer.
    • Development of a proposed clinical algorithm for cancer screening in cryptogenic stroke patients.

    Main Results:

    • Cryptogenic stroke patients may represent a unique population for identifying undiagnosed malignancies.
    • The proposed algorithm aims to systematically evaluate these patients for occult cancer.

    Conclusions:

    • A structured approach to cancer screening in cryptogenic stroke is warranted.
    • Further prospective clinical trials are necessary to validate the proposed screening algorithm and establish an evidence base for this clinical pathway.