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Predictors of trabecular bone score in school children
Summary
Trabecular bone score (TBS) in adolescents is influenced by age and puberty. While many factors correlate with TBS, age is an independent predictor only in girls after accounting for bone mineral content.
Area of Science:
- Bone biology and densitometry
- Pediatric bone health assessment
Background:
- Trabecular bone score (TBS) is a DXA-derived metric evaluating bone texture and microarchitecture.
- TBS provides supplementary skeletal information beyond bone mineral density (BMD) and clinical risk factors.
- Previous research indicates TBS independently predicts osteoporotic fracture risk in the elderly.
Purpose of the Study:
- To investigate the determinants of Trabecular bone score (TBS) in adolescents.
- To characterize the relationship between TBS, age, and pubertal stages in young individuals.
- To identify other potential predictors of TBS in the pediatric population.
Main Methods:
- Reanalyzed DXA scan images from 170 boys and 168 girls (age 10-17) using TBS software.
- Data were collected at baseline and 1-year follow-up from a prospective vitamin D trial.
- Statistical analyses included t-tests, Pearson's correlations, and regression analyses to assess predictors of TBS.
Main Results:
- Age, height, weight, sun exposure, spine and body BMC/BMD, and lean/fat mass were significantly correlated with TBS (p < 0.035).
- These correlations were most pronounced during late pubertal stages.
- After adjusting for bone mineral content (BMC), age remained an independent predictor of TBS solely in girls.
Conclusions:
- Univariate analyses identified age and pubertal stage as key determinants of TBS in adolescents.
- Further research is necessary to explore TBS predictors and its prognostic value for bone fragility in children and adolescents.
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