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Living With Genetic Vulnerability: a Life Course Perspective.

Rebekah J Hamilton1, Nancy A Innella2, Dawn T Bounds2

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Living with hereditary breast and ovarian cancer (HBOC) risk involves long-term family consequences. The life course perspective reveals how BRCA mutation results impact women differently by age, influencing genetic counseling strategies.

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Area of Science:

  • Genetics
  • Sociology
  • Psychology

Background:

  • Hereditary Breast and Ovarian Cancer (HBOC) risk impacts families long-term.
  • Genetic counseling for BRCA mutations requires understanding the lived experience.
  • The life course perspective (LCP) offers a framework for analyzing these experiences over time.

Purpose of the Study:

  • To explore the temporal and social context of living with BRCA mutation genetic test results.
  • To apply the LCP to longitudinal data from women with HBOC risk.
  • To understand how age influences the experience of genetic vulnerability.

Main Methods:

  • Secondary data analysis of a longitudinal, grounded theory study.
  • Thematic analysis of interviews with 16 women conducted over 8 years.
  • Application of LCP concepts to interpret participants' experiences.

Main Results:

  • BRCA mutation knowledge has enduring consequences for families.
  • Women's experiences align with LCP concepts, highlighting changes due to genetic vulnerability.
  • Age-specific emphases on LCP concepts were observed: linked lives (40-50s), human agency (30s), and timing of events (20s).

Conclusions:

  • The LCP provides valuable insights into the long-term impact of BRCA mutations.
  • Healthcare providers can use these findings to improve genetic counseling for women with HBOC risk.
  • Understanding age-related LCP concept emphasis can personalize genetic counseling approaches.