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Updated: Jan 19, 2026

A Bioinformatics Pipeline for Investigating Molecular Evolution and Gene Expression using RNA-seq
Published on: May 28, 2021
The ring of life hypothesis for eukaryote origins is supported by multiple kinds of data
James McInerney1, Davide Pisani2, Mary J O'Connell3
1Department of Biology, National University of Ireland Maynooth, Co. Kildare, Republic of Ireland Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK james.o.mcinerney@nuim.ie.
Abstract:
The literature is replete with manuscripts describing the origin of eukaryotic cells. Most of the models for eukaryogenesis are either autogenous (sometimes called slow-drip), or symbiogenic (sometimes called big-bang). In this article, we use large and diverse suites of 'Omics' and other data to make the inference that autogeneous hypotheses are a very poor fit to the data and the origin of eukaryotic cells occurred in a single symbiosis.
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