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Risk of incident atrial fibrillation in gout: a cohort study

Seoyoung C Kim1, Jun Liu2, Daniel H Solomon1

  • 1Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, Massachusetts, USA Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Annals of the Rheumatic Diseases
|September 2, 2015
PubMed

Insights

Gout patients have a modestly increased risk of developing atrial fibrillation (AF). This study found a higher incidence of AF in gout patients compared to those with osteoarthritis or no gout.

Area of Science:

  • Cardiology
  • Rheumatology
  • Epidemiology

Background:

  • Atrial fibrillation (AF) is a common arrhythmia linked to cardiovascular disease and mortality.
  • Emerging evidence suggests a connection between inflammation, hyperuricemia, and AF.
  • The specific risk of AF in patients with gout remains largely unexplored.

Purpose of the Study:

  • To investigate the association between gout and the risk of incident atrial fibrillation.
  • To compare AF risk in patients with gout versus osteoarthritis.
  • To evaluate AF risk in gout patients compared to a non-gout population.

Main Methods:

  • A cohort study utilizing US commercial insurance data from 2004-2013.
  • Identified patients with gout or osteoarthritis based on diagnoses and medication use.
  • Defined incident AF by new diagnosis and new medication dispensing; compared AF risk across groups.

Main Results:

  • The study included 70,015 patients with gout and 210,045 with osteoarthritis.
  • Gout patients showed a higher incidence rate of AF (7.19 per 1000 person-years) compared to osteoarthritis patients (5.87).
  • Gout was associated with a modestly increased risk of incident AF (HR 1.13-1.21) after adjusting for confounders.

Conclusions:

  • Gout is associated with a modestly increased risk of incident atrial fibrillation.
  • This association persists after accounting for other cardiovascular risk factors and comorbidities.
  • Findings highlight a potential link between gout and AF, warranting further investigation.
Abstract

Keywords:
Cardiovascular DiseaseEpidemiologyGout

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