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Updated: Apr 4, 2026
Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
Published on: April 15, 2022
Monoclonal gammopathy of undetermined significance: Using risk stratification to guide follow-up
Zia Uddin1, Diane Maennle1, Kimberly Russell1
1Northeast Ohio Medical University, Rootstown, OH, USA.
Abstract:
Varying combinations of 3 measurable factors determine a patient's risk of progressing toward multiple myeloma and influence monitoring decisions. This review--and accompanying algorithm--can guide your approach. For monoclonal gammopathy of undetermined significance (MGUS) patients at low risk, repeat serum protein electrophoresis (SPE) in 6 months. If no significant elevation of M-protein is found, repeat SPE every 2 to 3 years.
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