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Circulating androgens in hirsutism.

S Khandekar, V Lata, R J Dash

    The Journal of the Association of Physicians of India
    |October 1, 1989
    PubMed
    Summary
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    This study investigated androgen levels in women with hirsutism. Elevated testosterone, dihydrotestosterone, and androstenedione were found, with polycystic ovarian disease being a common diagnosis.

    Area of Science:

    • Endocrinology
    • Reproductive Health
    • Hirsutism Research

    Background:

    • Hirsutism affects women of reproductive age, often linked to hormonal imbalances.
    • Understanding androgen status is crucial for diagnosing the underlying cause of hirsutism.

    Purpose of the Study:

    • To evaluate androgen levels in women presenting with hirsutism.
    • To correlate clinical findings with hormonal profiles in hirsute women.

    Main Methods:

    • Studied 50 consecutive women of reproductive age with hirsutism.
    • Assessed clinical parameters including BMI and menstrual regularity.
    • Measured serum levels of testosterone, dihydrotestosterone, and androstenedione.

    Main Results:

    Related Experiment Videos

  • Significant elevations in testosterone (48%), dihydrotestosterone (38%), and androstenedione (86%) were observed in hirsute patients.
  • 42% of patients experienced menstrual disturbances, and 30% had severe hirsutism.
  • Polycystic ovarian disease (20 patients), nonclassical 21 hydroxylase deficiency (1 patient), and idiopathic hirsutism (29 patients) were diagnosed.

    • Conclusions:

    • Hirsutism in reproductive-aged women is frequently associated with elevated androgens.
    • Hormonal assessment is vital for differentiating causes of hirsutism, with PCOS being a prevalent diagnosis.