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Effect of iron deficiency on renal function.

B C Mehta, K B Patel, J B Mehta

The Journal of the Association of Physicians of India

|November 1, 1989

Summary

Iron deficiency anaemia impairs renal function, measured by three-hour creatinine clearance (THCC). Intravenous iron-dextran therapy significantly improves THCC within three days, independent of haemoglobin levels.

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Area of Science:

Nephrology
Hematology
Nutritional Science

Background:

Nutritional iron deficiency anaemia is a common condition.
Renal function can be affected by various systemic diseases.
The impact of iron deficiency anaemia on renal function requires further elucidation.

Purpose of the Study:

To assess renal function in patients with iron deficiency anaemia.
To evaluate the effect of intravenous iron-dextran therapy on renal function.

Main Methods:

Twenty patients with iron deficiency anaemia underwent assessment of three-hour creatinine clearance (THCC).
Renal function and haemoglobin levels were measured before and three days after total dose intravenous iron-dextran therapy.
Paired 't' test was used for statistical analysis.

Main Results:

Pre-therapy haemoglobin and THCC values showed no significant differences between measurements.
No significant difference was observed between pre- and post-therapy mean haemoglobin levels.
A statistically significant improvement in THCC was observed post-therapy (p < 0.01).

Conclusions:

Renal function, as indicated by THCC, is impaired in iron deficiency anaemia.
Intravenous iron-dextran therapy significantly improves renal function within three days, irrespective of haemoglobin changes.
The improvement suggests a direct effect of iron on tissue function beyond anaemia correction.

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