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Serum nickle estimation in acute myocardial infarction
The Journal of the Association of Physicians of India
|November 1, 1989
Summary
Serum nickel levels were significantly elevated in acute myocardial infarction patients up to 36 hours post-chest pain onset compared to healthy controls. This finding highlights nickel
Area of Science:
- Biochemistry
- Cardiology
- Environmental Health
Background:
- Elevated serum nickel levels have been investigated as a potential biomarker in various health conditions.
- Acute myocardial infarction (AMI) is a critical cardiovascular event requiring accurate diagnostic markers.
Purpose of the Study:
- To investigate the correlation between serum nickel concentrations and acute myocardial infarction (AMI).
- To determine if serum nickel can serve as a potential biomarker for AMI diagnosis.
Main Methods:
- Serum nickel levels were quantified using atomic absorption spectrometry.
- Measurements were taken from 20 healthy controls and 25 AMI patients at 12-hour intervals for up to 48 hours post-chest pain onset.
Main Results:
- Mean serum nickel in healthy controls was 0.27 micrograms/dl.
- Mean serum nickel in AMI patients showed elevated levels (0.40, 0.50, 0.49, 0.30 micrograms/dl) within the study period.
- Serum nickel levels were significantly higher (P < 0.001) in AMI patients up to 36 hours compared to controls.
Conclusions:
- Serum nickel levels are significantly elevated in patients with acute myocardial infarction (AMI) up to 36 hours after chest pain onset.
- These findings suggest that serum nickel may have potential as a diagnostic biomarker for AMI.