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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

91
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
91
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

262
Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
262
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
118
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

104
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
104
Modified-Release Drug Delivery Systems: Drug Release Characteristics01:22

Modified-Release Drug Delivery Systems: Drug Release Characteristics

190
Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...
190
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

112
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
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Controlled drug release for tissue engineering.

Kunal J Rambhia1, Peter X Ma2

  • 1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|September 2, 2015
PubMed
Summary
This summary is machine-generated.

This review covers advances in drug delivery for tissue engineering, focusing on hydrogels and scaffolds to achieve sustained release and minimize initial burst effects for better regenerative outcomes.

Keywords:
BiomaterialsControlled releaseDrug deliveryPolymerRegenerative medicineScaffoldTissue engineering

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Drug Delivery Systems

Background:

  • Tissue engineering integrates scaffolds, signaling molecules, and cells for tissue repair.
  • Controlled drug release is crucial for modulating cellular behavior and promoting regeneration.
  • Current methods face challenges with burst release and achieving long-term therapeutic effects.

Purpose of the Study:

  • To review recent advancements in controlled drug release from tissue engineering scaffolds.
  • To highlight strategies for reducing burst release and achieving sustained drug delivery.
  • To explore novel approaches like pulsatile and sequential drug delivery.

Main Methods:

  • Review of literature on hydrogels and porous scaffolds for drug delivery in tissue engineering.
  • Analysis of natural and synthetic polymer-based materials.
  • Examination of techniques to control drug release kinetics.

Main Results:

  • Hydrogels and porous scaffolds show promise for controlled drug release.
  • Strategies to mitigate burst release and enable sustained/long-term delivery are advancing.
  • Novel systems for pulsatile and sequential drug delivery are emerging.

Conclusions:

  • Significant progress has been made in controlled drug release for tissue engineering.
  • Further research is needed to overcome limitations and optimize delivery systems.
  • Optimized drug delivery is key to enhancing the efficacy of tissue engineering therapies.