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Updated: Apr 4, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Histone hyperacetylation and exon skipping: a calcium-mediated dynamic regulation in cardiomyocytes
Alok Sharma1, Hieu Nguyen, Lu Cai
1a Department of Genetics and Genome Sciences ; Case Western Reserve University ; Cleveland , OH USA.
Abstract:
In contrast to cell type-specific pre-mRNA alternative splicing, mechanisms controlling activity-dependent alternative splicing is under-studied and not well understood. In a recent study, we conducted a comprehensive analysis of calcium-mediated mechanism that regulates alternative exon skipping in mouse cardiomyocytes. Our results reveal a strong link between histone hyperacetylation and skipping of cassette exons, and provide support to the kinetic coupling model of the epigenetic regulation of alternative splicing at the chromatin level.
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