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A disposable sampling device to collect volume-measured DBS directly from a fingerprick onto DBS paper
Gabriel Lenk1, Sören Sandkvist2, Anton Pohanka2
1Department for Micro & Nanosystems, KTH Royal Institute of Technology, Osquldas väg 10, 10044 Stockholm, Sweden.
Background:
DBS samples collected from a fingerprick typically vary in volume and homogeneity and hence make an accurate quantitative analysis of DBS samples difficult.
Results:
We report a prototype which first defines a precise liquid volume and subsequently stores it to a conventional DBS matrix. Liquid volumes of 2.2 µl ± 7.1% (n = 21) for deionized water and 6.1 µl ± 8.8% (n = 15) for whole blood have been successfully metered and stored in DBS paper.
Conclusion:
The new method of collecting a defined volume of blood by DBS sampling has the potential to reduce assay bias for the quantitative evaluation of DBS samples while maintaining the simplicity of conventional DBS sampling.
