Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment Resistent Cancers02:56

Treatment Resistent Cancers

1.5K
1.5K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.3K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.3K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.9K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis of an unusual quinazoline alkaloid: theoretical and experimental investigations of its structural, electronic, molecular and biological properties.

RSC advances·2022
Same author

Synthesis of steroidal imidazolidinthiones as potential apoptotic agents: Investigation by theoretical and experimental studies.

Bioorganic chemistry·2018
Same author

Synthesis of Gallic-Acid-1-Phenyl-1H-[1,2,3]Triazol-4-yl Methyl Esters as Effective Antioxidants.

Drug research·2016
Same author

Isolation, characterization and HPLC quantification of compounds from Aquilegia fragrans Benth: Their in vitro antibacterial activities against bovine mastitis pathogens.

Journal of ethnopharmacology·2015
Same author

Design and Synthesis of Antitumor Heck-Coupled Sclareol Analogues: Modulation of BH3 Family Members by SS-12 in Autophagy and Apoptotic Cell Death.

Journal of medicinal chemistry·2015
Same author

LC-MS guided isolation, quantification and antioxidant evaluation of bioactive principles from Epimedium elatum.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2015
Same journal

Integrative in silico and in vitro Discovery of a Novel Thiazolidinone Derivative as Arginase Inhibitor with Potent Antileishmanial Activity.

Chemico-biological interactions·2026
Same journal

Sex- and size-dependent impacts of tire wear particles and zinc oxide nanoparticles on adult zebrafish: integrated evidence from physiology, gut microbiota networks, and hepatic transcriptomics.

Chemico-biological interactions·2026
Same journal

AMPK Activation by AICAR Mitigates Hypoxic Corneal Damage Through Rebuilding Energy and Metabolic Homeostasis.

Chemico-biological interactions·2026
Same journal

Interactions-Guided Blueprint of Acetylcholinesterase Binding: A Review on Structural and Molecular Determinants.

Chemico-biological interactions·2026
Same journal

Diazepam induces mitotic defects and cytotoxicity through modulation of tubulin and Eg5.

Chemico-biological interactions·2026
Same journal

Epigallocatechin-3-gallate, L-theanine and theophylline abolish high-glucose-induced renal cell senescence and subsequent epithelial-mesenchymal transition and fibroblast activation via SIRT1/PGC-1α axis: Implications for diabetic kidney disease.

Chemico-biological interactions·2026
See all related articles

Related Experiment Video

Updated: Apr 4, 2026

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma
10:02

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

2.7K

Arglabin: From isolation to antitumor evaluation.

Shabir H Lone1, Khursheed A Bhat1, Mohd A Khuroo2

  • 1Bioorganic Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Srinagar, 190005, Jammu and Kashmir, India.

Chemico-Biological Interactions
|September 2, 2015
PubMed
Summary
This summary is machine-generated.

Arglabin, a sesquiterpene lactone from Artemisia, exhibits potent antitumor activity by inhibiting farnesyl transferase (FTase). This action disrupts RAS proto-oncogene activation, a key factor in many human cancers.

Keywords:
AntitumorArglabinFarnesyl transferaseGuaianolideIsolationSynthesis

More Related Videos

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity
08:16

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

Published on: September 21, 2021

4.0K
Isolation and Characterization of Neutrophils with Anti-Tumor Properties
10:15

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

25.6K

Related Experiment Videos

Last Updated: Apr 4, 2026

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma
10:02

Isolation and Purification of Fungal β-Glucan as an Immunotherapy Strategy for Glioblastoma

Published on: June 2, 2023

2.7K
Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity
08:16

Caenorhabditis elegans as a Model System for Discovering Bioactive Compounds Against Polyglutamine-Mediated Neurotoxicity

Published on: September 21, 2021

4.0K
Isolation and Characterization of Neutrophils with Anti-Tumor Properties
10:15

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

25.6K

Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Cancer Biology

Background:

  • Arglabin is a guaianolide sesquiterpene lactone isolated from Artemisia species.
  • It possesses a complex 5,7,5-tricyclic ring system with five contiguous stereocenters.
  • Arglabin has demonstrated significant antitumor potential against various cancer cell lines.

Purpose of the Study:

  • To review the chemistry and biology of arglabin since its isolation in 1982.
  • To summarize isolation, structure elucidation, and stereochemical aspects.
  • To compile data on synthesis, modifications, and antitumor evaluations.

Main Methods:

  • Literature review of studies on arglabin.
  • Analysis of isolation and structure elucidation data.
  • Compilation of reported antitumor activity and mechanism of action studies.

Main Results:

  • Arglabin inhibits farnesyl transferase (FTase), an enzyme crucial for RAS proto-oncogene activation.
  • This inhibition disrupts the incorporation of farnesyl pyrophosphate into human H-ras proteins.
  • FTase inhibition is implicated in the antitumor effects observed in 20-30% of human tumors.

Conclusions:

  • Arglabin is a promising natural compound with a well-defined mechanism of antitumor action.
  • Its chemistry and biological activities have been extensively studied since 1982.
  • Further research into arglabin and its derivatives may lead to novel cancer therapeutics.