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Updated: Apr 4, 2026

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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
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Helical peptaibol mimics are better ionophores when racemic than when enantiopure
Sarah J Pike1, Jennifer E Jones, James Raftery
1School of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK. j.clayden@bristol.ac.uk.
Organic & Biomolecular Chemistry
|September 2, 2015
Abstract:
Helical peptide foldamers rich in α-aminoisobutyric acid (Aib) act as peptaibol-mimicking ionophores in the phospholipid bilayers of artificial vesicles. Racemic samples of these foldamers are more active than their enantiopure counterparts, which was attributed to differing propensities to form aggregates with crystal-like features in the bilayer.
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