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Management of regorafenib-related toxicities: a review

Saravanan K Krishnamoorthy1, Valerie Relias2, Sunit Sebastian3

  • 1Columbia University Medical Center, New York, New York, USA.

Therapeutic Advances in Gastroenterology
|September 2, 2015
PubMed

Insights

Regorafenib is an effective treatment for metastatic colorectal cancer (mCRC) after other therapies fail. This review details its efficacy and management of common side effects like hand foot skin reactions and fatigue.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Regorafenib is an oral multikinase inhibitor targeting tumor microenvironment and oncogenic kinases.
  • It exhibits a greater antiangiogenic effect compared to sorafenib.

Purpose of the Study:

  • To review the efficacy of regorafenib in metastatic colorectal cancer (mCRC).
  • To discuss the incidence and management of regorafenib's toxicities.

Main Methods:

  • Review of data from the CORRECT trial comparing regorafenib to placebo.
  • Analysis of adverse reactions associated with regorafenib treatment.

Main Results:

  • Regorafenib demonstrated efficacy in patients with mCRC who failed prior treatments.
  • Common severe adverse reactions include hand foot skin reactions, diarrhea, hypertension, and fatigue.

Conclusions:

  • Regorafenib is an FDA-approved treatment option for refractory mCRC.
  • Understanding and managing toxicities is crucial for patient care.
Keywords:
colon cancerhypertensionmetastaticrashregorafenib

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