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Related Concept Videos

Somatic to iPS Cell Reprogramming01:29

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Cellular Differentiation00:57

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How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
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Methods of Nuclear Reprogramming01:24

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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Lineage Commitment01:21

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Commitment is the  process whereby stem cells:
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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Updated: Apr 4, 2026

Cell Surface Marker Mediated Purification of iPS Cell Intermediates from a Reprogrammable Mouse Model
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Signaling involved in stem cell reprogramming and differentiation.

Shihori Tanabe1

  • 1Shihori Tanabe, National Institute of Health Sciences, Tokyo 158-8501, Japan.

World Journal of Stem Cells
|September 2, 2015
PubMed
Summary
This summary is machine-generated.

Stem cell differentiation and reprogramming involve complex signaling pathways. Understanding these molecular interactions is crucial for advancing stem cell research and therapeutic applications.

Keywords:
DifferentiationGeneGenomeReprogrammingSignalingStem cell

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Area of Science:

  • Life sciences
  • Stem cell biology
  • Molecular signaling

Background:

  • Stem cell differentiation is a fundamental biological process.
  • Recent advances allow reprogramming of differentiated cells into stem cells.
  • Signaling events critically regulate these cellular transitions.

Purpose of the Study:

  • To review molecular interactions and signaling pathways in stem cell differentiation.
  • To highlight the importance of signaling in stem cell reprogramming.
  • To provide insights into current research in life sciences.

Main Methods:

  • Literature review of signaling mechanisms.
  • Analysis of molecular interactions in stem cell reprogramming.
  • Discussion of signaling pathways regulating differentiation.

Main Results:

  • Multiple signaling events govern stem cell differentiation.
  • Specific signals are identified as key regulators of reprogramming.
  • The interplay between signaling and cellular fate is complex.

Conclusions:

  • Understanding stem cell signaling is vital for research.
  • Targeting signaling pathways may offer therapeutic potential.
  • Continued study of molecular interactions will advance stem cell science.