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Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
Circulating lncRNAs associated with occurrence of colorectal cancer progression
Jian Shi1, Xiaohua Li2, Fan Zhang3
1Department of Hepatobiliary Surgery, Binzhou Medical University Hospital 661 Second Huanghe Road, Binzhou 256603, China ; Department of General Surgery, Qilu Hospital of Shandong University 107 West Culture Road, Jinan, Shandong 250012, China.
Abstract:
Screening for the potential biomarker of colorectal cancer (CRC) is necessary to improve the early detection. The aim of this study was to investigate the potential of circulating cell-free long non-coding RNAs (lncRNA) as biomarkers of CRC. In this study, we applied an lncRNA microarray to screen the potential biomarker for CRC with a multi-stage validation and risk score formula detection. We discovered three lncRNA, XLOC_006844, LOC152578 and XLOC_000303, which were up-regulated in CRC comparing with the cancer-free controls with the merged area under curve (AUC) in training set and validation set of 0.919 and 0.975. The three lncRNAs might be the potential biomarker for the tumorigenesis prediction of CRC in the future.
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