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Current Perspectives on Epigenetic Modifications by Dietary Chemopreventive and Herbal Phytochemicals

Yue Guo1, Zheng-Yuan Su2, Ah-Ng Tony Kong2

  • 1Graduate Program in Pharmaceutical Sciences, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA ; Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

Current Pharmacology Reports
|September 2, 2015
PubMed

Insights

Epigenetic modifications like DNA methylation and histone changes drive cancer. Targeting these epigenetic alterations and dietary phytochemicals shows promise for cancer prevention and treatment.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, are increasingly recognized for their role in human cancer development.
  • These epigenetic changes interact with genetic defects, contributing to tumorigenesis.
  • The dynamic and reversible nature of epigenetic alterations makes them attractive targets for cancer therapy and biomarkers.

Purpose of the Study:

  • To review the current understanding of epigenetic alterations in carcinogenesis.
  • To highlight the potential of targeting epigenetic mechanisms for cancer treatment and prevention.
  • To discuss recent findings on dietary phytochemicals modulating epigenetic mechanisms for cancer chemoprevention.

Main Methods:

  • Literature review of studies on epigenetic modifications in cancer.
  • Analysis of recent research (past three years) on dietary phytochemicals and epigenetics.
  • Synthesis of current knowledge on epigenetic alterations and therapeutic strategies.

Main Results:

  • Epigenetic modifications are integral to cancer development, interacting with genetic factors.
  • Epigenetic therapies have gained approval for treating human cancers.
  • Dietary phytochemicals demonstrate potential in cancer chemoprevention by targeting epigenetic pathways.

Conclusions:

  • Targeting epigenetic alterations offers a promising strategy for cancer treatment and prevention.
  • Dietary phytochemicals represent a potential avenue for cancer chemoprevention through epigenetic modulation.
  • Further research into epigenetic mechanisms and phytochemical interventions is warranted.
Keywords:
Epigeneticchemopreventionphytochemicals

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