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Related Experiment Videos

Cardiovascular response to exercise in pacemaker implanted patients with fixed heart rate.

K Miyazawa1, I Yamaguchi, E Komatsu

  • 1Department of Clinical Laboratory, Yamagata University School of Medicine, Japan.

Japanese Heart Journal
|November 1, 1989
PubMed
Summary

Patients with fixed-rate ventricular pacing can increase stroke volume during exercise via the Frank-Starling mechanism, even with impaired cardiac output, if myocardial function is preserved.

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Area of Science:

  • Cardiology
  • Exercise Physiology

Background:

  • Complete atrioventricular block necessitates ventricular pacing, often with a fixed heart rate.
  • Understanding cardiovascular adaptation to exercise in these patients is crucial.

Purpose of the Study:

  • To investigate the cardiovascular response to supine exercise in patients with chronic ventricular pacing.
  • To compare exercise hemodynamics between paced patients and healthy controls.

Main Methods:

  • 11 patients with fixed-rate ventricular pacing and 11 healthy controls underwent supine exercise.
  • Measurements included oxygen uptake, cardiac output, stroke volume, and systolic arterial pressure.

Main Results:

  • Oxygen uptake increased linearly with work rate in both groups.

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  • Cardiac output was significantly lower in paced patients compared to controls.
  • Stroke volume increased similarly in both groups, driven by systolic emptying and the Frank-Starling mechanism.

    • Conclusions:

    • Ventricular pacing does not inherently limit stroke volume increase during exercise if myocardial function is adequate.
    • The Frank-Starling mechanism remains effective in paced individuals, compensating for fixed heart rates.
    • Exercise can be beneficial for improving stroke volume in patients with ventricular pacing and preserved myocardial function.