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Development of a prototype Open-close positron emission tomography system.

Seiichi Yamamoto1, Satoshi Okumura1, Tadashi Watabe2

  • 1Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.

The Review of Scientific Instruments
|September 3, 2015
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Summary

We developed a novel Open-close PET system with two imaging modes for enhanced flexibility. This new positron emission tomography (PET) system shows promise for applications in molecular imaging and proton therapy.

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Area of Science:

  • Medical Imaging
  • Nuclear Physics
  • Instrumentation

Background:

  • Positron emission tomography (PET) is a crucial molecular imaging technique.
  • Existing PET systems face limitations in artifact reduction and specialized applications.
  • A novel detector configuration is needed to overcome these challenges.

Purpose of the Study:

  • To develop and evaluate a prototype Open-close PET system.
  • To demonstrate the system's capability in both open and close detector configurations.
  • To assess its utility for molecular imaging and proton therapy applications.

Main Methods:

  • Designed a prototype PET system with a unique "Open-close" detector ring.
  • Utilized dual-decay time gadolinium orthosilicate (GSO) scintillators for depth-of-interaction detection.
  • Configured angled optical fiber image guides for a hexadecagonal detector arrangement.
  • Tested the system in both open-mode (separated rings) and close-mode (circular ring).

Main Results:

  • Achieved a spatial resolution of 2.4-mm FWHM in close-mode.
  • Demonstrated a sensitivity of 1.7% at the center of the field-of-view.
  • Successfully acquired projection and reconstructed images from (18)F-NaF rat studies and proton-irradiated phantoms.

Conclusions:

  • The Open-close PET system offers dual-mode imaging capabilities.
  • The system demonstrates potential for artifact-free imaging and specialized applications.
  • This innovative PET technology is suitable for both molecular imaging and proton therapy guidance.