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Related Experiment Video

Updated: Apr 4, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic.

Marine De Paoli¹, Paul Perco, Irmgard Mühlberger

¹a AXO Science SAS , Lyon , France .

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals

|September 3, 2015

Summary

A novel five-biomarker panel shows promise for diagnosing bladder cancer, offering a less invasive alternative to cystoscopy. Further studies are needed to confirm its clinical usefulness.

Keywords:

Biomarkers bladder cancer invasiveness recurrence

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Last Updated: Apr 4, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

Area of Science:

Urology
Oncology
Biochemistry

Background:

Urinary biomarkers offer a non-invasive diagnostic approach for bladder cancer.
Cystoscopy is the current standard but is invasive.

Purpose of the Study:

Identify a sensitive and specific biomarker panel for bladder cancer.
Assess the clinical utility of urinary biomarkers.

Main Methods:

Enzyme-linked immunosorbent assay (ELISA) was used to measure urinary biomarker concentrations.
Receiver operating characteristic (ROC) analysis evaluated marker performance.

Main Results:

A panel of five biomarkers (IL8, MMP9, VEGFA, PTGS2, and EN2) was identified.
This panel demonstrated superior performance compared to individual markers.

Conclusions:

The five-biomarker panel shows potential for bladder cancer diagnosis.
Further validation is required to establish clinical utility.