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Published on: February 25, 2011
Reactivity to sorbitan sesquioleate affects reactivity to fragrance mix I
Johannes Geier1, Axel Schnuch1, Holger Lessmann1
1Information Network of Departments of Dermatology, Georg-August University, 37075, Göttingen, Germany.
Background:
Fragrance mix I (FM I) and its single constituents contain 5% and 1% sorbitan sesquioleate (SSO), respectively. SSO is a rare sensitizer and a potential irritant.
Objectives:
To determine whether the outcome of the FM I breakdown test is affected by positive patch test reactivity to SSO.
Methods:
A retrospective analysis of data from the Information Network of Departments of Dermatology, 1998-2013, was performed.
Results:
The full FM I breakdown test including SSO was tested in 2952 patients. Of these, 154 (5.2%) had a positive patch test reaction to SSO 20% pet. and 2709 (91.8%) had a negative patch test reaction. Positive reactions to one or more of the single fragrances contained in the mix were significantly more common (82.5% versus 57.3%) in SSO-positive patients, who also had more multiple reactions than FM I-positive patients with negative SSO reactions (61.5% versus 21.3% patients with reactions to two or more fragrances).
Conclusions:
Our results indicate that reactivity to SSO markedly affects the outcome of patch testing with FM I and its single constituents. SSO must be an obligatory part of the full FM I breakdown test, and should ideally be included in the baseline series.
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