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Electrocardiogram abnormalities and heart rate variability in predicting mortality and cardiovascular events among

Silvia Badarau1, Dimitrie Siriopol2, Daniela Drugus3

  • 1Department of Nephrology, Gr. T. Popa University of Medicine and Pharmacy, Iasi, Romania. silvia.badarau@gmail.com.

International Urology and Nephrology
|September 3, 2015
PubMed

Insights

Electrocardiogram (ECG) interval changes during hemodialysis predict cardiovascular events and mortality in chronic kidney disease patients. Monitoring these ECG changes can improve patient outcomes.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomedical Engineering

Background:

  • Chronic hemodialysis patients face high risks of cardiovascular events and mortality.
  • Electrocardiographic (ECG) parameters and heart rate variability (HRV) are potential biomarkers for cardiovascular risk.
  • Understanding the relationship between ECG changes during hemodialysis and clinical outcomes is crucial.

Purpose of the Study:

  • To investigate the correlation between specific ECG parameters and HRV with cardiovascular events and mortality in patients undergoing chronic hemodialysis.
  • To identify predictive ECG markers for adverse cardiovascular outcomes in this population.

Main Methods:

  • A prospective study involving 116 asymptomatic chronic hemodialysis patients.
  • Ambulatory 24-hour Holter monitoring and pre- and post-hemodialysis ECGs were performed.
  • Measurements included ECG intervals (PR, QRS, QTc, QTc dispersion) and frequency-domain HRV measures (VLF, LF, HF, LF/HF ratio).

Main Results:

  • During follow-up, 11.2% died and 13.8% experienced a cardiovascular event.
  • The pre-post-dialysis difference in QTc interval was the strongest predictor of cardiovascular events.
  • Pre-dialysis QRS interval predicted all-cause mortality, while PR interval and VLF predicted both outcomes.

Conclusions:

  • Changes in ECG intervals during hemodialysis are significant predictors of cardiovascular events and mortality.
  • Routine monitoring of autonomic dysfunction and PR interval changes is recommended, especially for patients with suspected coronary artery disease.
Abstract

Keywords:
Autonomic dysfunctionElectrocardiogramHemodialysisHolter monitoringSurvival

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