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Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
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Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro

Published on: April 21, 2023

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Nanoparticles as potential new generation broad spectrum antimicrobial agents

Clarence S Yah1,2, Geoffrey S Simate3

  • 1Department of Biochemistry and Microbiology, Nelson Mandela Metropolitan University, Port Elizabeth, South Africa. cyah@nmmu.ac.za.

Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
|September 3, 2015
PubMed

Insights

Nanoparticle antimicrobial agents offer a promising solution to combat drug-resistant infections and treat intracellular pathogens, overcoming limitations of conventional treatments. Their broad-spectrum activity and unique properties are revolutionizing medicine and reducing disease burden.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Infectious Diseases

Background:

  • Rising antimicrobial resistance (AMR) complicates infection treatment and increases mortality.
  • Conventional antimicrobials struggle to penetrate cell membranes, hindering treatment of intracellular pathogens.
  • Intracellular pathogens persist within host cells, posing significant therapeutic challenges.

Purpose of the Study:

  • To review the current applications of nanoparticle (NP) antimicrobial agents.
  • To highlight the potential of NPs in overcoming limitations of conventional antimicrobials.
  • To discuss the future prospects of multifunctional NP-antimicrobial agents.

Main Methods:

  • Review of existing literature on NP-antimicrobial agents.
  • Analysis of physiochemical and functionalization properties of NPs.
  • Evaluation of NP efficacy in antimicrobial, sterilization, and wound healing applications.

Main Results:

  • Nanoparticle antimicrobial agents exhibit broad-spectrum activity against resistant strains.
  • NPs demonstrate efficacy as sterilization and wound healing agents.
  • NPs show potential for sustained inhibition of intracellular pathogens.

Conclusions:

  • Nanoparticle technology presents a potent strategy against antimicrobial resistance.
  • NPs can effectively treat infections caused by intracellular pathogens.
  • Multifunctional NP-antimicrobial agents are poised to revolutionize clinical medicine and reduce global disease burden.

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