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Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
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Coordinated Membrane Ballooning and Procoagulant Spreading in Human Platelets.

Ejaife O Agbani1, Marion T J van den Bosch2, Ed Brown2

  • 1From School of Physiology & Pharmacology, University of Bristol, United Kingdom (E.O.A., M.T.J.v.d.B., E.B., C.M.W., I.H., A.W.P.; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands (N.J.A.M., J.M.E.M.C., J.W.M.H.); and Welsh Blood Service and Arthur Bloom Haemophilia Centre, School of Medicine, Cardiff University, United Kingdom (P.W.C.). a.poole@bristol.ac.uk e.agbani@bristol.ac.uk.

Circulation
|September 3, 2015
PubMed
Summary

Platelet ballooning, a key part of hemostasis, is driven by fluid and ion entry, crucial for amplifying coagulation during thrombosis.

Keywords:
blood coagulationblood plateletscell-derived microparticlescollagenfluorescent imagingmembrane ballooningprocoagulant-spreading

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