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Induction of Colon Cancer in Mice with 1,2-Dimethylhydrazine
Kay E Gurley1, Russell D Moser1, Christopher J Kemp1
1Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109.
Cold Spring Harbor Protocols
|September 3, 2015
Abstract:
In this protocol, colon cancer is induced in mice through a series of injections with 1,2-dimethylhydrazine. Mice will develop primarily colon tumors starting at about 3 mo after the first injection. Tumors in the lung, uterus, and small intestine may also be seen, as well as lymphomas.