[Role of creatine phosphate in myocardial protection in heart surgery]

The Authors report their experience with the use of Creatine Phosphate (CP) in cardiac surgery. Forty patients undergoing mitral valve replacement are randomly divided into two groups: the former is treated with plain cardioplegia, the latter with CP-enriched cardioplegia at a concentration of 10 mmol/l. A sample of papillary muscle, obtained from the removed valve, is studied by means of spectrophotometric analysis in order to assess the enzyme activities and the intermediate metabolites of the different biochemical pathways of the myocardial cell. Our results suggest a possible interaction of exogenous CP with the cellular metabolism: all the mechanisms involved with the production of energy seem to be shifted towards a better preservation of the available pool of high-energy compounds.