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Published on: July 8, 2025
Renal dysfunction due to hydronephrosis by SAPHO syndrome: a case report
Katsura Kakoki1, Yasuyoshi Miyata1, Mikako Enokizono2
1Department of Urology, Nagasaki University Graduate School of Biomedical Sciences Nagasaki, Japan.
Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO) syndrome can cause hydronephrosis by compressing ureters. Magnetic Resonance Imaging (MRI) is recommended for evaluating upper urinary tract issues in SAPHO syndrome.
Area of Science:
- Rheumatology
- Nephrology
- Radiology
Background:
- Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO) syndrome is a rare autoinflammatory disorder.
- SAPHO syndrome typically presents with diverse mucocutaneous and skeletal manifestations.
Observation:
- This case report details a unique presentation of SAPHO syndrome.
- The patient developed hydronephrosis due to mechanical compression of bilateral ureters.
Findings:
- This is the first documented instance of hydronephrosis secondary to SAPHO syndrome.
- Magnetic Resonance Imaging (MRI) proved to be the most effective modality for assessing upper urinary tract involvement.
Implications:
- Highlights the potential for SAPHO syndrome to affect renal function through ureteral obstruction.
- Emphasizes the utility of MRI in diagnosing and managing urinary tract complications in SAPHO syndrome patients.
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