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Updated: Apr 4, 2026
Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
Published on: January 7, 2015
[Mitomycin extravasation after postoperative instillation]
Jorge Panach-Navarrete1, Cristina Ferrandis-Cortés2, María Ángeles Sales-Maicas3
1Urology Department. Hospital Clínico Universitario de Valencia. Valencia. Spain.
Objective:
To present the therapeutic management of severe complications related to postoperative mitomycin extravasation.
Methods:
Description of clinical cases, medical and surgical management and pathologic results of surgical specimens.
Results:
We report two cases of patients with extravesical mitomycin leakage after postoperative instillation. No bladder perforation was evident during tumor surgery. In both cases radical cystectomy was required.
Conclusions:
Postoperative mitomycin instillation may have undesirable consequences. The possible problems derived from its administration must be known, and each case must be individualized before administering this chemotherapy.
