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The possible impact of sortilin in reducing HBsAg expression in chronic hepatitis B

Sima Besharat1,2, Aezam Katoonizadeh1, Shirin Moossavi1

  • 1Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Medical Virology
|September 3, 2015
PubMed

Insights

Chronic hepatitis B patients show inverse association between hepatic Sortilin-1 (SORT1) gene expression and Hepatitis B surface antigen (HBsAg) levels. This suggests SORT1 may play a role in HBsAg particle formation during HBV infection.

Area of Science:

  • Hepatology
  • Virology
  • Molecular Biology

Background:

  • Hepatitis B virus (HBV) infection causes chronic liver disease, fibrosis, and cirrhosis globally.
  • Hepatitis B surface antigen (HBsAg) is a key marker in HBV infection, reflecting viral load.
  • Sortilin-1 (SORT1) is implicated in protein trafficking and degradation pathways.

Purpose of the Study:

  • To investigate the relationship between hepatic and serum HBsAg expression and hepatic SORT1 gene expression in chronic HBV patients.
  • To explore the potential role of SORT1 in the pathogenesis of chronic hepatitis B.

Main Methods:

  • Liver biopsies from 30 chronic hepatitis B patients were analyzed.
  • Hepatic HBsAg expression was assessed using immunohistochemistry.
  • Hepatic SORT1 gene expression was quantified using quantitative real-time PCR (qRT-PCR).

Main Results:

  • 90% of liver biopsies showed positive HBsAg staining.
  • A significant inverse association was found between hepatic HBsAg and SORT1 gene expression (β = -0.5, P = 0.042).
  • HBV DNA levels correlated with both hepatocyte and serum HBsAg titers, and ALT levels correlated with hepatic activity index.

Conclusions:

  • Hepatic SORT1 gene expression is inversely associated with hepatic HBsAg expression in chronic hepatitis B.
  • Sortilin-1 may be involved in the formation or regulation of Hepatitis B surface antigen particles.
  • Further research is warranted to elucidate the precise role of SORT1 in HBV pathogenesis.

Keywords:
HBV DNAHBsAgchronic hepatitis Bsortilin (SORT1)

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