Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.7K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.7K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

2.5K
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myeloid MMP14 couples extracellular proteolysis to inflammatory and metabolic remodeling during obesity.

Cell reports·2026
Same author

FBXL21 regulates diurnal proteostasis and stress response by targeting DNAJB6 and client proteins.

bioRxiv : the preprint server for biology·2026
Same author

The Liver Clock Tunes Transcriptional Rhythms in Skeletal Muscle to Regulate Mitochondrial Function.

Journal of biological rhythms·2026
Same author

Targeting the hepatic circadian clock concomitant with tyrosine kinase inhibition reverses late-stage hepatocellular carcinoma.

Cell reports·2025
Same author

The liver clock modulates circadian rhythms in white adipose tissue.

Molecular metabolism·2025
Same author

Decreased proliferation of HepG2 liver cancer cells in vitro and exhibited proteomic changes in vivo in subjects with metabolic syndrome and metabolic dysfunction-associated steatotic liver disease who performed four-week dawn-to-dusk dry fasting.

Clinical proteomics·2025

Related Experiment Video

Updated: Apr 4, 2026

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

3.0K

Phenotyping Circadian Rhythms in Mice.

Kristin Eckel-Mahan1,2, Paolo Sassone-Corsi1

  • 1University of California at Irvine, Department of Biological Chemistry, Center for Epigenetics and Metabolism, Irvine, California.

Current Protocols in Mouse Biology
|September 3, 2015
PubMed
Summary
This summary is machine-generated.

This study explores circadian rhythms in mice, focusing on how light influences the internal biological clock. Research methods analyze period length and plasticity, offering insights into human responses to disrupted sleep-wake cycles.

Keywords:
amplitudecircadianlightlocomotionperiodphasephotic entrainmenttau

More Related Videos

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters
07:44

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters

Published on: July 4, 2018

9.0K
In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

10.5K

Related Experiment Videos

Last Updated: Apr 4, 2026

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System
07:34

Manipulation of Rhythmic Food Intake in Mice Using a Custom-Made Feeding System

Published on: December 16, 2022

3.0K
In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters
07:44

In Vivo Monitoring of Circadian Clock Gene Expression in the Mouse Suprachiasmatic Nucleus Using Fluorescence Reporters

Published on: July 4, 2018

9.0K
In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
11:56

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells

Published on: September 28, 2017

10.5K

Area of Science:

  • Chronobiology
  • Neuroscience
  • Animal Models

Background:

  • Circadian rhythms are 24-hour cycles regulating physiological processes like sleep and hormone secretion.
  • Light is a key environmental cue that synchronizes the mammalian biological clock, primarily via the suprachiasmatic nucleus.
  • Studying circadian rhythms in model organisms is crucial for understanding their molecular basis and plasticity.

Purpose of the Study:

  • To present common methods for analyzing circadian periodicity and plasticity in mice.
  • To investigate how environmental light disruptions affect circadian rhythms.
  • To provide a framework for understanding human responses to circadian disruption.

Main Methods:

  • Analysis of entrainment processes in mice.
  • Determination of intrinsic circadian period (tau) under free-running conditions.
  • Assessment of circadian responses to light disruption and non-24-hour cycles (T-cycles).
  • Monitoring of locomotor activity in homecage environments.

Main Results:

  • Mice serve as a valuable model for circadian rhythm research due to genetic tractability and ease of activity monitoring.
  • Specific experimental paradigms allow for the measurement of circadian period length and adaptability.
  • The study outlines techniques to evaluate clock plasticity under various light conditions.

Conclusions:

  • Understanding circadian period properties like phase, amplitude, and length is vital.
  • These studies in mice can inform our knowledge of human responses to jet lag, shift work, and other circadian disruptions.
  • The presented methods facilitate the investigation of molecular mechanisms underlying circadian rhythmicity.