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Structure-Function Relationships of a Tertiary Amine-Based Polycarboxybetaine
Chen-Jung Lee1,2, Haiyan Wu1,2, Qiong Tang1,2
1Department of Chemical and Biomolecular Engineering and ‡Department of Mechanical Engineering, University of Akron , Akron, Ohio 44325, United States.
Langmuir : the ACS Journal of Surfaces and Colloids
|September 3, 2015
Summary
A new zwitterionic polymer, poly(2-((2-hydroxyethyl)(2-methacrylamidoethyl)ammonio)acetate) (PCBMAA-1T), offers excellent antifouling and buffering capabilities for biomedical uses. This material maintains protein resistance and pH stability, making it ideal for advanced medical applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Surface Chemistry
Background:
- Zwitterionic polycarboxybetaine (PCB) materials are valuable in biomedicine for their antifouling properties and adaptability.
- Materials with inherent buffering capacity are highly sought after for various biomedical applications.
- Existing zwitterionic materials often lack integrated buffering capabilities, limiting their utility in dynamic physiological environments.
Purpose of the Study:
- To synthesize and characterize a novel zwitterionic polymer, PCBMAA-1T, with combined antifouling and buffering properties.
- To investigate the structure-property relationships of zwitterionic materials, particularly the role of tertiary amine cations.
- To evaluate the protein resistance, pH buffering capacity, and stability of the synthesized material for potential biomedical applications.
Main Methods:
- Synthesis of poly(2-((2-hydroxyethyl)(2-methacrylamidoethyl)ammonio)acetate) (PCBMAA-1T) utilizing a tertiary amine cation.
- Surface plasmon resonance (SPR) sensing to quantify protein adsorption (fibrinogen, blood plasma, serum).
- Potentiometric titration to assess pH buffering capability across acidic and neutral/basic ranges.
- Evaluation of lactone ring stability in switchable zwitterionic systems.
Main Results:
- PCBMAA-1T exhibited excellent antifouling properties, with minimal protein adsorption (<0.8 ng/cm² for fibrinogen, <0.3 ng/cm² for plasma/serum).
- The tertiary amine cation provided effective buffering capacity, resisting pH changes between pH 1-3 and pH 7-9.
- The tertiary amine cation did not compromise antifouling performance and enhanced lactone ring stability in switchable materials.
- The synthesized material demonstrated superior all-in-one properties compared to existing zwitterionic materials.
Conclusions:
- PCBMAA-1T is a novel zwitterionic material with integrated antifouling and buffering capabilities, attributed to its tertiary amine cation.
- The material exhibits robust protein resistance and significant pH buffering capacity, suitable for demanding biomedical environments.
- This all-in-one zwitterionic polymer holds great potential for applications in tissue engineering, wound healing, and medical device coatings.
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