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Updated: Apr 4, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Malattached septum primum and deficient septal rim predict unsuccessful transcatheter closure of atrial
Stefan H Ostermayer1, Shubhika Srivastava1, John T Doucette2
1Division of Cardiology, Department of Pediatrics, the Mount Sinai Medical Center, New York, New York.
Objectives:
Assess impact of malattached septum primum (MASP) on transcatheter closure of interatrial communications.
Background:
Large defect size and deficient rims have been described as predictors for complications and unsuccessful device placement in closure of interatrial communications. MASP is an underappreciated morphologic atrial septal variation whose prevalence in isolated atrial communications and its influence on percutaneous device closure has not been systematically assessed.
Methods:
We retrospectively evaluated echocardiographic data of 328 patients scheduled for percutaneous secundum atrial septal defect (ASD) and patent foramen ovale (PFO) closure between January 2006 and January 2013. In ASD patients, defect size was measured by balloon stretch diameter while the length of the surrounding rims was measured in standard transthoracic and transesophageal views. Furthermore, the distance between septum primum and septum secundum as it attaches to the left atrial roof was evaluated in both, ASD and PFO patients. Septal anatomy of patients with procedural failure was compared to the anatomy of patients in whom the procedure was successful.
Results:
Transcatheter defect closure was successful in 131 (92.3%) of 142 ASD patients (32.3 years ± 24.7 years) and in all 186 PFO patients (49.6 years ± 16.2 years). Thirteen (4%) patients were found to have MASP (1.6 mm-13 mm). Smaller retroaortic rim, inferior rim, and the presence of a MASP were independently associated with procedural failure in ASD patients (P = 0.02, P = 0.03, and P = 0.003, respectively).
Conclusion:
Smaller retroaortic and inferior rims, as well as MASP are independent risk factors for unsuccessful transcatheter ASD closure.
Insights
Malattached septum primum (MASP) and deficient septal rims are key predictors of unsuccessful transcatheter closure for atrial septal defects (ASDs). Understanding these anatomical variations improves procedural success rates in patients undergoing interatrial communication closure.
Area of Science:
- Cardiology
- Medical Imaging
- Interventional Cardiology
Background:
- Transcatheter closure of interatrial communications can be complicated by large defect size and deficient rims.
- Malattached septum primum (MASP) is an underappreciated anatomical variation affecting atrial septal closure.
- The prevalence and impact of MASP on percutaneous closure of atrial communications remain under-evaluated.
Purpose of the Study:
- To assess the impact of malattached septum primum (MASP) on transcatheter closure of interatrial communications.
- To identify anatomical predictors of procedural failure in transcatheter closure of secundum atrial septal defects (ASDs) and patent foramen ovale (PFO).
Main Methods:
- Retrospective evaluation of echocardiographic data from 328 patients undergoing ASD or PFO closure.
- Measurement of defect size, rim length, and MASP presence using transthoracic and transesophageal echocardiography.
- Comparison of septal anatomy between patients with successful and failed procedures.
Main Results:
- Transcatheter closure was successful in 92.3% of ASD patients and 100% of PFO patients.
- Malattached septum primum (MASP) was identified in 4% of patients.
- Smaller retroaortic rim, inferior rim, and the presence of MASP were independently associated with procedural failure in ASD closure.
Conclusions:
- Smaller retroaortic and inferior rims are independent risk factors for unsuccessful transcatheter ASD closure.
- Malattached septum primum (MASP) is an independent risk factor for unsuccessful transcatheter ASD closure.
- Identifying these anatomical factors can help predict and potentially mitigate procedural failures.
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