Cardiac Adrenergic Nervous System and Left Ventricular Remodeling
Rohan Samson1, Hassan Baydoun, Abhishek Jaiswal
1Tulane University Heart and Vascular Institute (RS, HB, AJ, THLJ), Tulane University School of Medicine, New Orleans, Louisiana.
The American Journal of the Medical Sciences
|September 3, 2015
Summary
Cardiac adrenergic nervous system (ANS) overactivity is linked to worsening heart failure and left ventricular (LV) remodeling. Understanding the mechanisms may reveal new therapeutic targets for heart failure treatment.
Area of Science:
- Cardiology
- Neurocardiology
- Pharmacology
Background:
- Systolic heart failure is associated with increased cardiac adrenergic nervous system (ANS) activity.
- The relationship between cardiac ANS activation and left ventricular (LV) remodeling is not fully understood.
- Cardiac norepinephrine spillover is a marker of sympathetic nervous system activity.
Purpose of the Study:
- To review the evidence linking cardiac ANS activation to LV remodeling and heart failure progression.
- To explore the mechanisms of beta-adrenergic receptor blockade in mitigating LV remodeling.
- To discuss alternative strategies for managing cardiac ANS activation in heart failure.
Main Methods:
- Review of human and experimental data on cardiac ANS activation and LV remodeling.
- Analysis of beta-adrenergic receptor signaling pathways.
- Discussion of therapeutic approaches targeting the cardiac ANS.
Main Results:
- A strong temporal association exists between cardiac ANS activation and LV remodeling in heart failure.
- Beta-adrenergic receptor blockade demonstrates beneficial effects on LV remodeling.
- The precise mechanisms linking ANS activation to remodeling require further elucidation.
Conclusions:
- Cardiac ANS activation is closely linked to LV remodeling in heart failure.
- Further research into the underlying mechanisms may yield novel therapeutic strategies.
- Targeting the cardiac ANS offers potential for improved heart failure management.
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