Related Experiment Video
Updated: Apr 4, 2026
07:24
Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
6.9K
Long non-coding RNA: A new paradigm for lung cancer
Akanksha Khandelwal1, Albino Bacolla2, Karen M Vasquez2
1Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh, India.
Molecular Carcinogenesis
|September 3, 2015
Summary
Long non-coding RNAs (lncRNAs) are key regulators in biological processes and disease. This review details lncRNAs in lung cancer, highlighting their roles, diagnostic potential, and therapeutic implications.
Area of Science:
- Molecular Biology
- Genomics
- Oncology
Background:
- Lung cancer is a leading cause of cancer mortality globally.
- Long non-coding RNAs (lncRNAs) are a novel class of non-coding RNAs implicated in various biological processes.
- Deregulation of lncRNAs is associated with human diseases, including cancer.
Purpose of the Study:
- To provide a comprehensive survey of lncRNAs associated with lung cancer.
- To focus on the functions of lncRNAs in facilitating or inhibiting lung cancer progression and involved pathways.
- To discuss the emerging role of lncRNAs as biomarkers for cancer diagnosis and prognosis.
Main Methods:
- Comprehensive literature review of lncRNAs in lung cancer.
- Analysis of lncRNA biogenesis and molecular functions.
- Examination of relationships between lncRNAs, genome-wide transcription, and lung cancer.
Main Results:
- lncRNAs play significant roles in lung cancer development and progression.
- lncRNAs can act as facilitators or inhibitors of lung cancer.
- lncRNAs show promise as biomarkers for lung cancer diagnosis and prognosis.
Conclusions:
- Understanding lncRNA functions in lung cancer is critical for developing novel biomarkers and therapeutic strategies.
- lncRNAs represent promising targets for future lung cancer therapies.
- Further research into lncRNA-genome interactions is essential for advancing lung cancer treatment.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
10.2K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.2K
02:39lncRNA - Long Non-coding RNAs
3.9K
3.9K
03:18Non-LTR Retrotransposons
14.0K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
14.0K
01:22MicroRNAs
4.3K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
4.3K
01:22MicroRNAs
24.7K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.7K
01:20Types of RNA
16.3K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
16.3K