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Long non-coding RNA: A new paradigm for lung cancer

Akanksha Khandelwal1, Albino Bacolla2, Karen M Vasquez2

  • 1Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh, India.

Molecular Carcinogenesis
|September 3, 2015
PubMed

Insights

Long non-coding RNAs (lncRNAs) are key regulators in biological processes and disease. This review details lncRNAs in lung cancer, highlighting their roles, diagnostic potential, and therapeutic implications.

Area of Science:

  • Molecular Biology
  • Genomics
  • Oncology

Background:

  • Lung cancer is a leading cause of cancer mortality globally.
  • Long non-coding RNAs (lncRNAs) are a novel class of non-coding RNAs implicated in various biological processes.
  • Deregulation of lncRNAs is associated with human diseases, including cancer.

Purpose of the Study:

  • To provide a comprehensive survey of lncRNAs associated with lung cancer.
  • To focus on the functions of lncRNAs in facilitating or inhibiting lung cancer progression and involved pathways.
  • To discuss the emerging role of lncRNAs as biomarkers for cancer diagnosis and prognosis.

Main Methods:

  • Comprehensive literature review of lncRNAs in lung cancer.
  • Analysis of lncRNA biogenesis and molecular functions.
  • Examination of relationships between lncRNAs, genome-wide transcription, and lung cancer.

Main Results:

  • lncRNAs play significant roles in lung cancer development and progression.
  • lncRNAs can act as facilitators or inhibitors of lung cancer.
  • lncRNAs show promise as biomarkers for lung cancer diagnosis and prognosis.

Conclusions:

  • Understanding lncRNA functions in lung cancer is critical for developing novel biomarkers and therapeutic strategies.
  • lncRNAs represent promising targets for future lung cancer therapies.
  • Further research into lncRNA-genome interactions is essential for advancing lung cancer treatment.
Keywords:
biogenesisbiomarkerslncRNAlong non-coding RNAlung cancer

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