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Screening for congenital coagulation disorders.

A Tripodi1

  • 1Centro Emofilia e Trombosi Angelo Bianchi Bonomi, Università degli Studi ed Ospedale Maggiore, Milano.

La Ricerca in Clinica E in Laboratorio
|October 1, 1989
PubMed
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Diagnosing congenital coagulation disorders requires a two-step lab screening. This approach effectively identifies common and rare bleeding abnormalities for accurate diagnosis.

Area of Science:

  • Hematology
  • Clinical Diagnostics

Background:

  • Congenital coagulation disorders are a significant cause of bleeding.
  • Accurate diagnosis is crucial for effective management.

Purpose of the Study:

  • To outline a comprehensive screening procedure for diagnosing congenital coagulation disorders.
  • To differentiate between common and rare hemostatic abnormalities.

Main Methods:

  • Detailed personal and family clinical history collection.
  • A two-step laboratory screening process.
  • Initial screening includes bleeding time, platelet count, prothrombin time, and activated partial thromboplastin time.

Main Results:

  • The first step identifies frequent causes of hemorrhage.

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  • The second step detects less common hemostatic abnormalities in patients with a bleeding history but normal initial results.
  • Second-step tests include factor XIII, antiplasmin, platelet factor 3, von Willebrand factor, tissue plasminogen activator, and dysfibrinogenemia assays.

    • Conclusions:

    • A systematic, two-step screening strategy is effective for diagnosing congenital coagulation disorders.
    • This approach ensures detection of both common and rare hemostatic defects.