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Therapeutic drug monitoring of targeted anticancer therapy

Laurent A Decosterd1, Nicolas Widmer2,3, Khalil Zaman4

  • 1Laboratory of Clinical Pharmacology, Service of Biomedicine, Lausanne University Hospital & University of Lausanne, Switzerland.

Biomarkers in Medicine
|September 4, 2015
PubMed

Insights

Targeted anticancer therapies offer new hope for cancer patients. Individualizing drug doses using therapeutic drug monitoring (TDM) can improve treatment effectiveness and reduce side effects.

Area of Science:

  • Oncology
  • Pharmacology
  • Cancer Therapeutics

Background:

  • Oral targeted anticancer therapies are transforming cancer treatment, managing malignancies as chronic conditions.
  • Challenges remain, including drug resistance, cancer stem cells, and adverse effects, limiting long-term cure.
  • Treatment response is affected by tumor genetics and variable drug concentrations, yet fixed doses are standard.

Purpose of the Study:

  • To explore optimizing targeted anticancer therapy through individualizing dosage.
  • To investigate the role of therapeutic drug monitoring (TDM) in enhancing treatment outcomes.

Main Methods:

  • Review of current challenges in targeted anticancer therapy.
  • Discussion of pharmacokinetic variability and fixed dosing limitations.
  • Proposal of therapeutic drug monitoring (TDM) for personalized dosing.

Main Results:

  • Individualized dosing based on TDM can optimize therapeutic responses.
  • TDM can help minimize the risk of major adverse reactions.
  • Personalized drug concentrations are key to maximizing efficacy and safety.

Conclusions:

  • Therapeutic drug monitoring (TDM) offers a strategy to optimize oral targeted anticancer therapies.
  • Individualized dosing can improve patient outcomes by increasing response probability and reducing toxicity.
  • Integrating TDM into clinical practice is crucial for maximizing the benefits of novel cancer drugs.
Keywords:
blood concentrationsdrug dosage adaptationliquid chromatography-tandem mass spectrometrypersonalized medicinepharmacokineticsprotein kinase inhibitorstargeted anticancer therapytherapeutic drug monitoring

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