Related Experiment Video
Updated: Apr 4, 2026

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Contemporaneous Dual Catalysis: Aldol Products from Non-Carbonyl Substrates
Barry M Trost1, Jacob S Tracy2
1Department of Chemistry, Stanford University, Stanford, CA 94305 (USA). bmtrost@stanford.edu.
Abstract:
The aldol reaction represents an important class of atom-economic carbon-carbon bond-forming reactions vital to modern organic synthesis. Despite the attention this reaction has received, issues related to chemo- and regioselectivity as well as reactivity of readily enolizable electrophiles remain. To help overcome these limitations, a new direct approach toward aldol products that does not rely upon carbonyl substrates is described. This approach employs room-temperature contemporaneous lanthanum/vanadium dual catalysis, whereby a vanadium-catalyzed 1,3-transposition of allenols is coupled with a lanthanum-catalyzed Meinwald rearrangement of epoxides in situ to directly form aldol products.
Related Concept Videos
Base-Catalyzed Aldol Addition Reaction
Acid-Catalyzed Aldol Addition Reaction
C–C Bond Formation: Aldol Condensation Overview
Crossed Aldol Reaction Using Strong Bases: Directed Aldol Reaction
Crossed Aldol Reactions: Overview
Intramolecular Aldol Reaction

