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Pubertal timing and a family history of hypertension: Prospective cohort study

Wei Zheng1, Kohta Suzuki1, Miri Sato2

  • 1Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanishi, Japan.

Pediatrics International : Official Journal of the Japan Pediatric Society
|September 4, 2015
PubMed

Insights

Children with a family history of hypertension may experience earlier pubertal growth spurts. This early pubertal timing is linked to a higher likelihood of developing hypertension later in life.

Area of Science:

  • Pediatrics
  • Genetics
  • Cardiovascular Health

Background:

  • Hypertension is a heritable condition with genetic factors influencing its development from childhood.
  • Puberty represents a critical developmental stage that may be associated with the onset of adult hypertension.

Purpose of the Study:

  • To investigate the association between a family history of hypertension and pubertal growth timing in children.
  • To determine if early pubertal development is linked to a predisposition for hypertension.

Main Methods:

  • Utilized data from the prospective Project Koshu cohort study in Japan (1991-1998).
  • Collected data on family history of hypertension, maternal, birth, and early life factors via questionnaires.
  • Calculated child age at peak height velocity (PHV) using anthropometric data from annual school check-ups.

Main Results:

  • Analyzed data from 919 children (479 boys, 440 girls), with 478 having a family history of hypertension.
  • Found an association between early age at peak height velocity and a family history of hypertension (OR, 1.52; P=0.03) after adjusting for confounders.
  • Specifically, early PHV was linked to having at least one maternal hypertensive relative (OR, 1.81; P=0.003).

Conclusions:

  • The timing of pubertal growth appears to play a role in hypertension development among individuals with a family history.
  • These findings, combined with existing literature, suggest early pubertal timing is a factor in hypertension development for at-risk individuals.
  • Further research is warranted to confirm these associations.
Abstract

Keywords:
childrencohort studyfamily historyhypertensionpuberty

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