[Successful local treatment of nail psoriasis with 5-fluorouracil]

Topical application of 5-fluorouracil (5-FU) has proved effective in the therapy of psoriasis of the nail. Over a period of 6 months, we treated 114 patients with 1% 5-FU liquid and 59 patients with 20% urea plus 1% 5-FU cream twice daily. An improvement of more than 50% of the clinical signs of psoriasis, such as oil spots, subungual hyperkeratosis, and combined signs, was achieved after treatment with urea + 5-FU cream.