Association of ambulatory arterial stiffness index with sEPCR in newly diagnosed hypertensive patients

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Hakki Yilmaz1, Muzaffer Cakmak2, Osman Inan3

  • 1a Department of Internal Medicine, Section of Nephrology , Dr. A. Y. Ankara Oncology Training and Research Hospital , Ankara , Turkey .

Renal Failure
|September 4, 2015
PubMed

Insights

Newly diagnosed hypertension is linked to increased arterial stiffness, measured by the ambulatory arterial stiffness index (AASI). This stiffness correlates with higher levels of soluble endothelial protein C receptor (sEPCR), a marker of hypercoagulation.

Area of Science:

  • Cardiovascular Medicine
  • Hypertension Research
  • Vascular Biology

Background:

  • Increased arterial stiffness is a known risk factor for cardiovascular diseases.
  • Hypertensive patients are prone to thrombotic events, potentially linked to hypercoagulable states.
  • Soluble endothelial protein C receptor (sEPCR) is a marker associated with hypercoagulation.

Purpose of the Study:

  • To investigate the association between arterial stiffness, measured by the ambulatory arterial stiffness index (AASI), and plasma sEPCR levels.
  • To explore the role of arterial stiffness in the development of a hypercoagulable state in newly diagnosed hypertensive patients.

Main Methods:

  • The study included 263 newly diagnosed essential hypertensive patients and 55 healthy normotensive controls.
  • Twenty-four-hour ambulatory blood pressure monitoring (ABPM) was performed to derive AASI.
  • Plasma sEPCR levels were quantified using ELISA.

Main Results:

  • Hypertensive patients exhibited significantly higher AASI, C-reactive protein (CRP), and sEPCR compared to controls.
  • Univariate analysis revealed positive associations between AASI and age, body mass index, pulse pressure, plasma sEPCR, and 24-h heart rate.
  • Multivariate analyses confirmed independent correlations of sEPCR and HDL with AASI.

Conclusions:

  • Elevated AASI in newly diagnosed hypertensive patients is associated with increased sEPCR levels.
  • This association suggests that increased arterial stiffness may contribute to a hypercoagulable state.
  • The findings may have implications for understanding and managing thrombotic complications in hypertension.
Abstract

Keywords:
Ambulatory arterial stiffness indexarterial stiffnesshypertensionsEPCRthrombosis

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