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L-dopa absorption and the pituitary-hypothalamic axis.

A E Boyd, G Angoff, A Long

    The Journal of Clinical Endocrinology and Metabolism
    |December 1, 1978
    PubMed
    Summary
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    Oral L-dopa affects growth hormone (GH) and prolactin (PRL) levels, but absorption variability doesn't fully explain these changes or body temperature effects.

    Area of Science:

    • Neuroendocrinology
    • Pharmacology

    Background:

    • Oral L-dopa is a neuropharmacological tool for assessing the pituitary-hypothalamic axis.
    • The impact of L-dopa absorption on its physiological effects is not well understood.

    Purpose of the Study:

    • To investigate the relationship between gastrointestinal absorption of oral L-dopa and subsequent changes in plasma growth hormone (GH), prolactin (PRL), and body temperature.
    • To explore the variability in these physiological responses.

    Main Methods:

    • 14 male volunteers received 1.0 g of oral L-dopa.
    • Plasma L-dopa, GH, and PRL levels were measured.
    • Rectal and skin temperatures were recorded.
    • Data were compared with a placebo group (24 men).

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    Main Results:

    • L-dopa absorption varied significantly (peak levels at 30-230 min).
    • Plasma GH increased, while PRL levels decreased significantly post-L-dopa.
    • Rectal temperature showed a significant decrease in some individuals.
    • GH response correlated with L-dopa absorption and inversely with basal GH levels.

    Conclusions:

    • Variability in GH, PRL, and body temperature responses to oral L-dopa is not solely due to absorption differences.
    • Suggests differential sensitivity or distinct mechanisms/sites of action for L-dopa's effects on GH secretion, PRL suppression, and thermoregulation.