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Updated: Apr 4, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
The analysis of microRNAs miR-200C and miR-145 expression in colorectal cancer of different molecular subtypes
Y A Shelygin1, V P Shubin, S A Frolov
1State Scientific Center of Coloproctology, ul. Salyama Adilya 2, Moscow, 123423, Russia.
Abstract:
The expression levels of microRNAs miR-200c and miR-145 in two groups of colorectal cancer differing by the presence/absence of epithelial-mesenchymal transition (EMF) were studied. In the EMF-positive cancer, the level of miR-145 is increased, whereas the level of miR-200c is reduced. The reverse situation is observed in the EMI-negative cancer. MiR-145 can serve as a marker of the mesenchymal subtype of cancer. Gene expression profiles and microRNAs allow prognostically unfavorable tumors of the mesenchymal subtype to be distinguished.
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