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Treatment of advanced thyroid cancer: role of molecularly targeted therapies

Lorinda L Covell1, Apar Kishor Ganti

  • 1Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.

Targeted Oncology
|September 4, 2015
PubMed

Insights

Advanced thyroid cancer lacks effective chemotherapy options. Molecularly targeted therapies, including multi-kinase inhibitors like sorafenib, vandetanib, and cabozantinib, now offer new treatment avenues for specific thyroid cancer subtypes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Advanced thyroid cancer is largely resistant to traditional chemotherapy.
  • Understanding molecular pathways has opened doors for targeted treatments.

Purpose of the Study:

  • To review current literature on advanced thyroid carcinoma treatment.
  • To discuss future directions in managing advanced thyroid cancer.

Main Methods:

  • Literature review of studies on advanced thyroid cancer.
  • Analysis of clinical trials involving molecularly targeted therapies.
  • Summary of US FDA-approved drugs for thyroid cancer.

Main Results:

  • Multi-kinase inhibitors show promise in treating advanced thyroid cancer.
  • Sorafenib is approved for differentiated thyroid cancer.
  • Vandetanib and cabozantinib are approved for medullary thyroid carcinoma.

Conclusions:

  • Targeted therapies represent a significant advancement in treating advanced thyroid cancer.
  • Further research is needed to explore novel therapeutic strategies.

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