Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental pancreatic cancer.

P M Pour1

  • 1Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha 68105.

The American Journal of Surgical Pathology
|January 1, 1989
PubMed
Summary

This study on induced pancreatic cancer in hamsters reveals that ductal cells are tumor progenitors and altered hormone secretions are key. Early detection and therapy may be possible using anti-A antibodies targeting a tumor-specific antigen.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early diagnosis of pancreatic cancer: neutrophil gelatinase-associated lipocalin as a marker of pancreatic intraepithelial neoplasia.

British journal of cancer·2008
Same author

Class III beta-tubulin, a marker of resistance to paclitaxel, is overexpressed in pancreatic ductal adenocarcinoma and intraepithelial neoplasia.

Histopathology·2007
Same author

Retinoic acid can induce markers of endocrine transdifferentiation in pancreatic ductal adenocarcinoma: preliminary observations from an in vitro cell line model.

Journal of clinical pathology·2006
Same author

Diabetes mellitus: a risk factor for pancreatic cancer?

Langenbeck's archives of surgery·2004
Same author

MUC4 mucin expression in human pancreatic tumours is affected by organ environment: the possible role of TGFbeta2.

British journal of cancer·2004
Same author

Immortalization with telomerase of the Nestin-positive cells of the human pancreas.

Biochemical and biophysical research communications·2003

Area of Science:

  • Oncology
  • Gastroenterology
  • Carcinogenesis

Background:

  • Pancreatic cancer research benefits from animal models.
  • Understanding carcinogenesis mechanisms is crucial for effective treatments.

Purpose of the Study:

  • To investigate the mechanisms and histogenesis of experimentally induced pancreatic cancer in hamsters.
  • To identify potential biomarkers for early detection and therapeutic targets.

Main Methods:

  • Induction of pancreatic cancer in hamsters using specific carcinogens.
  • Analysis of tumor histogenesis and cellular origins.
  • Assessment of humoral effects and endocrine pancreas function.
  • Detection of blood group-related antigens, including A antigen.

Main Results:

  • Carcinogens act humorally, not via bile reflux.
  • Ductal/ductular cells are the progenitor cells of induced tumors.
  • Endocrine cell proliferation is linked to functional pancreatic abnormalities and altered hormone secretions.
  • A antigen is a tumor-specific antigen characteristic of early cancer development.

Conclusions:

  • Experimentally induced pancreatic cancer in hamsters provides valuable insights into disease mechanisms.
  • Anti-A antibody shows promise for early detection and therapy of pancreatic cancer.

Related Experiment Videos